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An acylhydrazone coumarin as chemosensor for the detection of Ni2+ with excellent sensitivity and low LOD: Synthesis, DFT calculations and application in real water and living cells
- Source :
- Inorganica Chimica Acta. 516:120144
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- A novel acylhydrazone coumarin fluorescent chemosensor C4 for detection of Ni2+ was designed and synthesized. The experimental results revealed a low detection limit of 2.1 × 10−11 M with high selectivity and excellent sensitivity towards Ni2+. C4 showed a good linear relationship with the concentration of Ni2+ from 1.3 × 10−6 to 1.6 μM. Moreover, a stable complex was formed between C4 and with Ni2+ and the binding ratio was proved to be 2: 1 by Job’s plot and mass spectrum. The sensing ability of C4 towards Ni2+ was attributed to parity-forbidden transition according to fluorescence titrations and DFT calculations. The detection of Ni2+ in water samples illustrated C4 could be successfully applied for the detection of Ni2+ in real environmental samples. What’s more, the fluorescence microscopy images of Hela cells demonstrated the high potential of the novel biosensor for the investigation of biological processes involving Ni2+, as well.
- Subjects :
- inorganic chemicals
Detection limit
010405 organic chemistry
Chemistry
Inorganic chemistry
010402 general chemistry
Coumarin
01 natural sciences
Fluorescence
0104 chemical sciences
Inorganic Chemistry
chemistry.chemical_compound
cardiovascular system
Materials Chemistry
Mass spectrum
Fluorescence microscope
Titration
Sensitivity (control systems)
Physical and Theoretical Chemistry
tissues
Biosensor
Subjects
Details
- ISSN :
- 00201693
- Volume :
- 516
- Database :
- OpenAIRE
- Journal :
- Inorganica Chimica Acta
- Accession number :
- edsair.doi...........ca29888d8b7f7b1d91124c91ffe505da