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Outcomes of patients with moderate-to-severe Ischemia excluded from the ischemia trial
- Source :
- Journal of Nuclear Cardiology. 29:1100-1105
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- The International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial showed no difference in outcomes between medical therapy vs coronary revascularization in the management of patients with stable coronary artery disease. We aimed to determine the percentage of patients with at least moderate ischemia that would have been eligible for enrollment and evaluate the outcomes of those who would not. Consecutive patients who underwent cardiac single-photon emission computed tomography (SPECT) between April 2016 and September 2019 were identified and all-cause mortality was determined. There were a total of 1508 patients (mean age 67 ± 11.6 years, 69.5% males) with any perfusion defect on SPECT. Patients had a high prevalence of cardiac risk factors (73.4% with hypertension and 54.4% with diabetes mellitus.) Nearly half (709, 47%) had moderate-to-severe ischemia but over two-thirds (479/709, 66.3%) had at least one ISCHEMIA trial exclusion criteria. Patients meeting ISCHEMIA enrollment criteria had a significantly lower all-cause mortality than those who would have been excluded (3.91% vs. 11.3%, respectively, P
- Subjects :
- Moderate to severe
medicine.medical_specialty
medicine.diagnostic_test
business.industry
Ischemia
medicine.disease
Lower risk
Coronary revascularization
Coronary artery disease
Diabetes mellitus
Internal medicine
medicine
Cardiology
Radiology, Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine
business
Perfusion
Emission computed tomography
Subjects
Details
- ISSN :
- 15326551 and 10713581
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Journal of Nuclear Cardiology
- Accession number :
- edsair.doi...........c9c76845c0849bc79b0b61c32267d426