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[Untitled]
- Source :
- Bulletin of Experimental Biology and Medicine. 131:511-514
- Publication Year :
- 2001
- Publisher :
- Springer Science and Business Media LLC, 2001.
-
Abstract
- Extracellular recording was used to study the effect of sodium nitroprusside, a donor of NO, on parameters of action potential and ionic currents in single sciatic nerve fibers and unmyelinated nerve terminals in the sternal muscle in frogs. Sodium nitroprusside significantly decreased the duration of action potential in Ranvier node and the amplitude of afterdepolarization. In motor nerve terminals bathed in low Ca2+ saline, sodium nitroprusside increased phase III amplitude of the nerve terminal response corresponding to outward potas-sium currents. Blockade of voltage-dependent potassium channels with 4-aminopyridine abolished the effects of NO. These data indicate that exogenous NO reduced the duration of action potential and afterdepolarization through enhancement of voltage-dependent potassium currents.
- Subjects :
- Potassium
Unmyelinated nerve fiber
Motor nerve
chemistry.chemical_element
Nerve fiber
General Medicine
General Biochemistry, Genetics and Molecular Biology
Potassium channel
Afterdepolarization
medicine.anatomical_structure
chemistry
Anesthesia
medicine
Biophysics
Sodium nitroprusside
Sciatic nerve
medicine.drug
Subjects
Details
- ISSN :
- 00074888
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- Bulletin of Experimental Biology and Medicine
- Accession number :
- edsair.doi...........c9997fc6b936fd806c1b097e0512c7e1