Hyperamilasemia Determined in the Course of Ebstein-Barr Virus Infection

Macroenzymes are high molecular weight enzymes which could be in the serum in physiologic or pathologic conditions. The first described and the most frequently seen macroenzyme is macroamylase. Here we present a child with macroamylasemia. A 3-year-old boy was brought to the hospital with fever and cervical swelling. On his examination, multiple number of cervical lymphadenopathies, hepatomegaly and splenomegaly were detected. Acute Ebstein-Barr virus (EBV) infection was considered in the patient who had fever, cervical lymphadenopathies, hepatomegaly, and splenomegaly and atypical lymphocytes on the peripheral smear. On laboratory findings, amylase levels were elevated which was thought to be a secondary complication, like parotitis, secondary to EBV infection. During follow-ups of the patient monitored without any treatment, complaints and all findings regressed, while amylase levels coursed at high levels. Salivary gland ultrasound (US) performed to find the cause of elevated amylase levels, findings which might be secondary to viral infection were seen. On the abdominal USG, pancreas was normal but minimal splenomegaly was detected. Fractional clearance of amylase was determined as