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A new class of phosphanucleosides containing a 3-hydroxy-1-hydroxymethylphospholane 1-oxide ring
- Source :
- Tetrahedron. 69:9120-9129
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Novel phosphanucleosides containing a 3-hydroxy-1-hydroxymethylphospholane 1-oxide ring were synthesized as compounds with potential biological activity. A double Arbuzov reaction was employed to prepare a phospholene precursor, which was then converted into an epoxide and subsequently into racemic phosphanucleoside via nucleobase construction.
Details
- ISSN :
- 00404020
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Tetrahedron
- Accession number :
- edsair.doi...........c8d74bb067b2be89008db6edf2f806c0