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Autologous bone marrow transplantation for advanced stage adult lymphoblastic lymphoma in first complete remission
- Source :
- Annals of Oncology. 2:181-185
- Publication Year :
- 1991
- Publisher :
- Elsevier BV, 1991.
-
Abstract
- Summary Thirty-six successive adult patients with lymphoblastic lymphoma entered a study of sequential chemotherapy consisting of an intensive LSA2-L2-type protocol to induce first complete remission. Eighteen patients in first CR (median age 22 years, range 15–51), underwent autologous bone marrow transplantation after receiving a conditioning regimen consisting of cyclophosphamide and total body irradiation. Of these 18 patients, 2 were in stage III and 16 in stage IV; 15 showed mediastinal and 9 bone marrow involvement at diagnosis. The transplant procedure was well tolerated and no treatment-induced deaths occurred. At this time, 14 out of 18 patients are alive and well between 1 and 60 months post transplant (median follow-up time 46 months) with an actuarial disease-free survival of 74%. This phase II study suggests that high-dose chemo-radiotherapy followed by autologous bone marrow transplantation may improve long-term disease-free survival in advanced stage adult lymphoblastic lymphoma.
- Subjects :
- medicine.medical_specialty
Cyclophosphamide
business.industry
Lymphoblastic lymphoma
Phases of clinical research
Hematology
Total body irradiation
medicine.disease
Chemotherapy regimen
Surgery
Non-Hodgkin's lymphoma
Transplantation
medicine.anatomical_structure
Oncology
medicine
Bone marrow
business
medicine.drug
Subjects
Details
- ISSN :
- 09237534
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Annals of Oncology
- Accession number :
- edsair.doi...........c8d6978e096879052b3a3c29261f3e95