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A structural analog of the protosterol cation is not a strong inhibitor of sterol biosynthesis

Authors :
Donnette C. Daley
E. J. Corey
Cheng Hengmiao
Source :
Tetrahedron Letters. 37:3287-3290
Publication Year :
1996
Publisher :
Elsevier BV, 1996.

Abstract

The relatively modest potency of inhibition of lanosterol synthase by the tetracyclic ammonium ion 10, a structural analog of the protosterol cation 4, IC50 = 22 μM, indicates that the protosterol cation is not strongly bound by the enzyme.

Details

ISSN :
00404039
Volume :
37
Database :
OpenAIRE
Journal :
Tetrahedron Letters
Accession number :
edsair.doi...........c8b65a68c3b160d07a738d3879fbdcc1
Full Text :
https://doi.org/10.1016/0040-4039(96)00577-1