Back to Search
Start Over
A structural analog of the protosterol cation is not a strong inhibitor of sterol biosynthesis
- Source :
- Tetrahedron Letters. 37:3287-3290
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- The relatively modest potency of inhibition of lanosterol synthase by the tetracyclic ammonium ion 10, a structural analog of the protosterol cation 4, IC50 = 22 μM, indicates that the protosterol cation is not strongly bound by the enzyme.
Details
- ISSN :
- 00404039
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........c8b65a68c3b160d07a738d3879fbdcc1
- Full Text :
- https://doi.org/10.1016/0040-4039(96)00577-1