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Controlled synthesis of polypeptides
- Source :
- Chinese Chemical Letters. 31:3001-3014
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Polypeptides are one kind of promising biodegradable and biocompatible biomedical polymers with the structural units of various α-amino acids. Polypeptides were first polymerized by the ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCAs) by Leuchs and Hermann in 1906. In the past decades, several effective strategies, including the selection of initiators, the adjustment of reaction conditions, and the introduction of catalysts, have been reported to improve the controllability of the ROP of various α-amino acid NCAs to synthesize different polypeptides with precise chemical structures and low polydispersity indexes. In this Review, the strategies, mechanisms, challenges, and opportunities for controlled synthesis of polypeptides by the ROP of different α-amino acid NCAs have been declared.
- Subjects :
- Reaction conditions
Chemistry
Biomedical polymers
Dispersity
02 engineering and technology
General Chemistry
010402 general chemistry
021001 nanoscience & nanotechnology
Biocompatible material
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
Catalysis
Polymerization
0210 nano-technology
Subjects
Details
- ISSN :
- 10018417
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Chinese Chemical Letters
- Accession number :
- edsair.doi...........c865314a098ec0433497d35d71d47ba5