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68Ga-PSMA Positron Emission Tomography/Computed Tomography Provides Accurate Staging of Lymph Node Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer
- Source :
- European Urology. 70:553-557
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- We evaluated the accuracy of 68Ga-prostate-specific membrane antigen-HBED-CC (68Ga-PSMA) positron emission tomography/computed tomography (PET/CT) for nodal staging prior to lymph node dissection (LND) in patients with prostate cancer (PCa). Thirty-four patients with histologically proven PCa underwent 68Ga-PSMA-HBED-CC PET/CT prior to radical prostatectomy with primary LND (pLND; n=20) and PET/CT prior to secondary LND (sLND; n=14). Accuracy of PET and CT were analysed separately for staging of the following 71 lymph node (LN) regions: pelvic left (n=30), pelvic right (n=31), presacral (n=3), and para-aortic (n=7). Postoperative histopathology was taken as a reference standard. Thirty-seven of 71 (52%) regions showed LN metastases on histopathology. Sensitivity, specificity, positive predictive value, and negative predictive value for detection of LN metastases were 84%, 82%, 84%, and 82% for PET criteria and 65%, 76%, 75%, and 67% for CT criteria. PET was more accurate for nodal staging compared with CT both at pLND (88% vs 75%) and sLND (77% vs 65%). Overall, 68Ga-PSMA PET/CT provides accurate nodal staging prior to pLND and sLND for PCa. PATIENT SUMMARY: 68Ga-PSMA positron emission tomography/computed tomography is accurate in detecting tumour spread to lymph nodes before patients undergo surgery for prostate cancer.
- Subjects :
- medicine.medical_specialty
PET-CT
medicine.diagnostic_test
Prostatectomy
business.industry
Urology
medicine.medical_treatment
medicine.disease
030218 nuclear medicine & medical imaging
03 medical and health sciences
Dissection
Prostate cancer
0302 clinical medicine
medicine.anatomical_structure
Positron emission tomography
030220 oncology & carcinogenesis
medicine
Histopathology
Radiology
Lymph
business
Lymph node
Subjects
Details
- ISSN :
- 03022838
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- European Urology
- Accession number :
- edsair.doi...........c855bba0dc0f716159c94f2a8d81927c