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Association Between MTHFR C677T Polymorphism and Congenital Heart Disease
- Source :
- International Heart Journal. 61:553-561
- Publication Year :
- 2020
- Publisher :
- International Heart Journal (Japanese Heart Journal), 2020.
-
Abstract
- Many published studies have evaluated the association between the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) polymorphism and the risk of congenital heart disease (CHD); however, the specific conclusion is still controversial.To get a more accurate conclusion, we used a meta-analysis to evaluate the association between the MTHFR gene C677T polymorphism and the risk of CHD.Based on the design-based search strategy, a comprehensive literature search was conducted on PubMed, OVID, Cochrane Library, Embase, Wanfang, CNKI, and Web of Science. We selected the Newcastle-Ottawa Scale (NOS) to assess the quality of the included studies. We performed a heterogeneity test on the results of the study and calculated the combined odds ratios (ORs) and its corresponding 95% confidence intervals (95% CIs) under a random- or fixed-effect model. Subgroup analyses were conducted by ethnicity, source of controls, sample size, and genotyping method. Sensitivity analysis was used to insure authenticity of this meta-analysis result. Egger's test and Begg's funnel plot were performed to detect publication bias.Eventually, our meta-analysis included 15 eligible studies. We observed a significant correlation between the MTHFR C677T polymorphism and the development of CHD in the recessive model (OR: 1.35, 95% CI: 1.06-1.71, P = 0.006) for the overall population. In subgroups stratified by ethnicity and source of controls, subgroup analyses indicated similar associations in Asians and hospital-based groups, but not for Caucasians and population-based groups. Egger's test and Begg's funnel plot demonstrated no significant publication bias in our study.Our analysis identified that MTHFR C677T allele is a risk genetic for CHD development, especially in Asians compared with Caucasians.
- Subjects :
- medicine.medical_specialty
education.field_of_study
Funnel plot
biology
business.industry
Population
Single-nucleotide polymorphism
General Medicine
Odds ratio
Publication bias
030204 cardiovascular system & hematology
Confidence interval
03 medical and health sciences
0302 clinical medicine
Internal medicine
Methylenetetrahydrofolate reductase
biology.protein
Medicine
030212 general & internal medicine
Cardiology and Cardiovascular Medicine
business
education
Genotyping
Subjects
Details
- ISSN :
- 13493299 and 13492365
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- International Heart Journal
- Accession number :
- edsair.doi...........c7d3968a6a8fcd1b1ce462d0cf8b9dad