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Genome-wide association study identifies novel candidate malaria resistance genes in Cameroon
- Source :
- Human Molecular Genetics.
- Publication Year :
- 2023
- Publisher :
- Oxford University Press (OUP), 2023.
-
Abstract
- Recent data suggest that only a small fraction of severe malaria heritability is explained by the totality of genetic markers discovered so far. The extensive genetic diversity within African populations means that significant associations are likely to be found in Africa. In their series of multi-site genome-wide association studies (GWAS) across sub-Saharan Africa, the Malaria Genomic Epidemiology Network (MalariaGEN) observed specific limitations and encouraged country-specific analyses. Here, we present findings of a GWAS of Cameroonian participants that contributed to MalariaGEN projects (n = 1103). We identified protective associations at polymorphisms within the enhancer region of CHST15 [Benjamin–Hochberg false discovery rate (FDR)
- Subjects :
- Genetics
General Medicine
Molecular Biology
Genetics (clinical)
Subjects
Details
- ISSN :
- 14602083 and 09646906
- Database :
- OpenAIRE
- Journal :
- Human Molecular Genetics
- Accession number :
- edsair.doi...........c7b4fcea74ef6f05c6f6f0028d1b542a