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Efficacy of short-term adjunctive subantimicrobial dose doxycycline in diabetic patients - randomized study
- Source :
- Oral Diseases. 18:763-770
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Oral Diseases (2012) 18, 763–770 Objective: To investigate the effectiveness of short-term adjunctive subantimicrobial dose doxycycline (SDD) treatment in patients with diabetes mellitus type 2 and chronic periodontitis (CP). Methods: Thirty-four patients with CP and type 2 diabetes mellitus were included in the placebo-controlled, double-blind study. After scaling and root planing (SRP), patients were randomly assigned to two groups, receiving either SDD or placebo bid for 3 months. The probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), approximal plaque index, glycated hemoglobin (HbA1c) level were recorded and gingival crevicular fluid (GCF) samples were collected at baseline and after 3-month therapy for the estimation of matrix metalloproteinase-8 levels. Results: Clinical attachment level, PD, and BOP improved significantly in both groups after therapy (P
- Subjects :
- Periodontitis
medicine.medical_specialty
business.industry
Bleeding on probing
Dentistry
medicine.disease
Placebo
Gastroenterology
Chronic periodontitis
law.invention
chemistry.chemical_compound
Scaling and root planing
Otorhinolaryngology
Randomized controlled trial
chemistry
law
Diabetes mellitus
Internal medicine
medicine
Glycated hemoglobin
medicine.symptom
business
General Dentistry
Subjects
Details
- ISSN :
- 1354523X
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Oral Diseases
- Accession number :
- edsair.doi...........c717bcec01a3741ee1e476b1124cc1c1
- Full Text :
- https://doi.org/10.1111/j.1601-0825.2012.01943.x