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Reduced transforming growth factor-β1 production by mononuclear cells from patients with active chronic idiopathic thrombocytopenic purpura
- Source :
- British Journal of Haematology. 116:862-867
- Publication Year :
- 2002
- Publisher :
- Wiley, 2002.
-
Abstract
- Chronic idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder in which activated T-helper (Th) cells and different Th-cell cytokines might play an important role. We have recently reported that chronic ITP patients in remission had elevated plasma levels of the Th3 cytokine transforming growth factor-beta1 (TGF-beta1), possibly as a part of a bystander immune suppression. In the present study we found that, in ITP patients with active disease [platelet count (plc) 150 x 10(9)/l (1894 +/- 244 pg/ml; n =12; P
- Subjects :
- biology
business.industry
medicine.medical_treatment
Hematology
Transforming growth factor beta
medicine.disease
Thrombocytopenic purpura
Peripheral blood mononuclear cell
Pathogenesis
Immune system
Cytokine
immune system diseases
hemic and lymphatic diseases
Immunopathology
Immunology
biology.protein
medicine
Platelet
business
Subjects
Details
- ISSN :
- 00071048
- Volume :
- 116
- Database :
- OpenAIRE
- Journal :
- British Journal of Haematology
- Accession number :
- edsair.doi...........c707da3e23b69bcdd8171ce50d4e199d