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Influence of Bile Salts as Excipients in Ranitidine, Aminophylline and Phenobarbital Tablets on Dissolution Rate
- Source :
- Clinical Pharmacology & Biopharmaceutics.
- Publication Year :
- 2017
- Publisher :
- OMICS Publishing Group, 2017.
-
Abstract
- Aim: The aim of this study is to investigate the influence of bile salts, sodium cholate, sodium 12-ketocholate and sodium dehydrocholate, as excipients in ranitidine, aminophylline and phenobarbital tablets on dissolution rate. Methods: Four groups of tablets (control without bile salts and three investigational groups containing different bile salts) were prepared for three different drug substances: ranitidine, aminophylline and phenobarbital. Dissolution rate was measured. Results: Dissolution rate is increased significantly in all investigational groups comparing to the control group in all three drug substances. Discussion: Presented results are very favourable and encouraging in case of dissolution enhancing and should be further investigated, especially in drug substances that are classified in class II and IV as per Biopharmaceutical Classification System (BCS) classification. Conclusion: Bile acid salts are very promising excipients, proven to act as surfactants and as lubricants. Running title: Bile salts as excipients in ranitidine, aminophylline and phenobarbital tablets.
- Subjects :
- Drug
medicine.drug_class
media_common.quotation_subject
Sodium
Excipient
chemistry.chemical_element
Pharmacology
030226 pharmacology & pharmacy
01 natural sciences
Ranitidine
03 medical and health sciences
0302 clinical medicine
0103 physical sciences
medicine
Sodium Cholate
media_common
Chromatography
010304 chemical physics
Bile acid
business.industry
General Medicine
chemistry
Phenobarbital
Aminophylline
business
medicine.drug
Subjects
Details
- ISSN :
- 2167065X
- Database :
- OpenAIRE
- Journal :
- Clinical Pharmacology & Biopharmaceutics
- Accession number :
- edsair.doi...........c6f4549f20f51668c3f03930de499310