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Clinical profiles and intraoperative identification of complex glands in stage I lung adenocarcinoma
- Source :
- European Journal of Cardio-Thoracic Surgery. 63
- Publication Year :
- 2023
- Publisher :
- Oxford University Press (OUP), 2023.
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Abstract
- OBJECTIVESThis study aimed to investigate the potential of complex glandular patterns (CGP) in lymph node micrometastasis (LNMM) and to determine the clinical beneficiaries in stage I lung adenocarcinoma (LUAD) with CGP. Meanwhile, the feasibility of detecting CGP on frozen section was also evaluated.METHODSWe retrospectively analysed the clinicopathological characteristics of 848 pathologic-stage I LUADs. A logistic regression model and a Cox proportional-hazards model were conducted to define the risk factors for LNMM and survival respectively. Furthermore, 5 pathologists reviewed frozen sections of 100 LUADs independently.RESULTSThe logistic regression model indicated that CGP [odds ratio 3.89, 95% confidence interval (CI) 2.46–6.15; P CONCLUSIONSLNMM was more frequently observed in stage I LUAD with CGP. Adequate lymphadenectomy and adjuvant chemotherapy were associated with improved survival in CGP-present patients, especially in CGP-present/LNMM-positive subgroup. Additionally, it is feasible to identify CGP on frozen section intraoperatively.
Details
- ISSN :
- 1873734X
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- European Journal of Cardio-Thoracic Surgery
- Accession number :
- edsair.doi...........c6b7194fff55297d595eeda9f72aa048