MnI2-catalyzed regioselective intramolecular iodoamination of unfunctionalized olefins

Authors :: Hui Sun
Yueming Li
Gong-Qing Liu
Bin Cui
Source :: Tetrahedron. 72:7170-7178
Publication Year :: 2016
Publisher :: Elsevier BV, 2016.
Abstract: MnI2-catalyzed intramolecular iodoamination of unfunctionalized olefins was reported. Interaction of MnI2 with N-alkenyl amine/sulfonamide gave NRMnI which produced a CH2MnI intermediate via intramolecular aminometallation of C C double bond. Reductive elimination of CH2I from CH2MnI produced iodomethyl heterocycle with the release of Mn(0) which was confirmed by XPS and XRD experiments.

Subjects :: chemistry.chemical_classification
Double bond
010405 organic chemistry
Organic Chemistry
Regioselectivity
010402 general chemistry
01 natural sciences
Biochemistry
Medicinal chemistry
Reductive elimination
0104 chemical sciences
Catalysis
Sulfonamide
chemistry
X-ray photoelectron spectroscopy
Intramolecular force
Drug Discovery
Organic chemistry
Amine gas treating

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