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Patients with metastatic renal cell carcinoma treated with cabozantinib in the Czech Republic: analysis of four cancer centers
- Source :
- Biomedical Papers. 166:97-104
- Publication Year :
- 2022
- Publisher :
- Palacky University Olomouc, 2022.
-
Abstract
- Aim The aim of this study was to retrospectively analyze treatment outcomes and tolerance in patients in whom cabozantinib was used after previous targeted therapy. Patients and methods Cabozantinib was administered in dose 60 mg/day, a subset of patients received initial dose of 40 mg/day. The treatment was administered until to progression or unacceptable toxicity. CT scans were assessed according to the RECIST 1.1 and toxicity of treatment was assessed based on the CTCAE (version 4). Kaplan-Meier analysis was used to calculate progression free survival (PFS) and overall survival (OS). We performed a multivariate analysis of risk factors for treatment outcomes (PFS, OS) by Cox regression analysis. All statistics were evaluated at the significance level alpha = 0.05. Results 54 patients with metastatic renal cell carcinoma (mRCC) were evaluated. Median PFS in all patients treated with cabozantinib was 9.3 months (95% CI 5.3 - 13.3). One-year survival was 85.2% (95% CI 72.9 - 93.4%). Treatment response was observed in 45.9% of cases, including one complete remission. Cox regression analysis demonstrated that presence of subsequent treatment was the only factor with a significant effect on OS (P=0.008). Adverse events occurred in 88.9% of patients, grade 3 - 4 in 46.3%. Conclusion The analysis of our cohort of patients treated with cabozantinib in the second or higher lines of treatment showed that cabozantinib represents an effective and safe therapy and contributes to longer survival of our mRCC patients.
- Subjects :
- Oncology
medicine.medical_specialty
Cabozantinib
business.industry
Proportional hazards model
Cancer
030204 cardiovascular system & hematology
medicine.disease
General Biochemistry, Genetics and Molecular Biology
3. Good health
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
chemistry
Renal cell carcinoma
030220 oncology & carcinogenesis
Internal medicine
Statistical significance
Cohort
medicine
Progression-free survival
business
Adverse effect
Subjects
Details
- ISSN :
- 18047521 and 12138118
- Volume :
- 166
- Database :
- OpenAIRE
- Journal :
- Biomedical Papers
- Accession number :
- edsair.doi...........c642cdf78a2446e03d6a284085472c25