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Development of Poly(Vinyl Alcohol)-Collagen-Hydroxyapatite Nanohybrids for Tissue Grafting

Authors :
Guiqiu Zheng
Xudong Li
Zhongwei Gu
Xing Dong Zhang
Xiao Min Wang
Xiaoliang Wang
Source :
Key Engineering Materials. :329-332
Publication Year :
2007
Publisher :
Trans Tech Publications, Ltd., 2007.

Abstract

Poly(vinyl alcohol) (PVA) was introduced during in situ synthesis of hydroxyapatite (HA) in neutral collagen (COL) solution and final PVA-COL-HA nanohybrids were achieved via sequential steps including gelation by fibrillogenesis, freezing-thawing physical crosslinking, removal of unreacted residues and dehydration. This method is expected to endow the pure PVA with good bioactivity and meanwhile the presence of elastic PVA would improve the properties of COL-HA composites. The phase, microstructure and possible molecular interactions of the achieved PVA-COL-HA nanohybrids were analyzed by using X-ray diffraction, Fourier transform infra-red spectroscopy and scanning electron microscopy. The results indicate that the inorganic phase is poorly crystallized apatite with a nanometer size due to the confinement of organic macromolecules which forms a network structure.

Details

ISSN :
16629795
Database :
OpenAIRE
Journal :
Key Engineering Materials
Accession number :
edsair.doi...........c63127ca4dc2f52aca3bafe3264166f4
Full Text :
https://doi.org/10.4028/www.scientific.net/kem.330-332.329