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Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats

Authors :
Giuliano Grignaschi
E Fanelli
Rosario Samanin
I Scagnol
Source :
British Journal of Pharmacology. 127:1190-1194
Publication Year :
1999
Publisher :
Wiley, 1999.

Abstract

The effect of the 5-hydroxytryptamine (5-HT) and noradrenaline (NA) reuptake inhibitor sibutramine was studied in food deprived, neuropeptide Y (NPY)- or muscimol-injected rats. Sibutramine dose-dependently reduced feeding caused by food-deprivation (ED50=5.1±0.8 mg kg−1) or by NPY injection into the paraventricular nucleus of the hypothalamus (ED50=6.0±0.5 mg kg−1). The increase in food intake caused by muscimol injected into the dorsal raphe was not modified by sibutramine (1–10 mg kg−1). The hypophagic effect of 5.1 mg kg−1 sibutramine in food-deprived rats was studied in rats pretreated with different serotonin receptor antagonists. Metergoline (non-selective, 0.3 and 1.0 mg kg−1), ritanserin (5-HT2A/2C, 0.5 and 1.0 mg kg−1) and GR127935 (5-HT1B/1D, 0.5 and 1.0 mg kg−1) did not modify the hypophagic effect of sibutramine, while SB206553 (5-HT2B/2C, 5 and 10 mg kg−1) slightly but significantly reduced it (Fint(2.53)=3.4; P

Details

ISSN :
00071188
Volume :
127
Database :
OpenAIRE
Journal :
British Journal of Pharmacology
Accession number :
edsair.doi...........c620165bbaf2f8897b9abe1fed02d497
Full Text :
https://doi.org/10.1038/sj.bjp.0702633