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Antidiarrheal Activity of the Fruits ofVitex doniana. in Laboratory Animals
- Source :
- Pharmaceutical Biology. 46:387-392
- Publication Year :
- 2008
- Publisher :
- Informa UK Limited, 2008.
-
Abstract
- The effect of different doses of the aqueous extract of Vitex doniana. Sweet (Verbenaceae) on acetylcholine and histamine-induced contractions on isolated guinea pig ileum was evaluated. The effect of the extract on intestinal peristalsis and castor oil–induced diarrhea in mice was also studied. The results showed that the extract possess a concentration-dependent inhibition of both acetylcholine and histamine-induced contractions. The extract (at doses of 150–650 mg/kg) also inhibited gastric peristalsis in mice fed charcoal meal and significantly protected mice against castor oil–induced diarrhea. Phytochemical screening of the extract revealed the presence of anthraquinones, flavonoids, saponins, sterols, and tannins. The findings in this study indicate that the aqueous extract of V. doniana. fruits may contain some pharmacologically active components that perhaps will be useful as antidiarrheal agents. The findings have also validated the use of this plant in traditional cure of diarrhea.
- Subjects :
- Pharmacology
Traditional medicine
Verbenaceae
Pharmaceutical Science
General Medicine
Antidiarrheal Agent
Biology
biology.organism_classification
Small intestine
Diarrhea
chemistry.chemical_compound
medicine.anatomical_structure
Complementary and alternative medicine
Phytochemical
Biochemistry
chemistry
Drug Discovery
Anthraquinones
medicine
Molecular Medicine
medicine.symptom
Acetylcholine
medicine.drug
Peristalsis
Subjects
Details
- ISSN :
- 17445116 and 13880209
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical Biology
- Accession number :
- edsair.doi...........c607edf2a19b9a0c4bca24727afe57b8