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Antibody to Ga1NAc-GD1a and Ga1NAc-GM1b in Guillain—Barré syndrome subsequent to Campylobacter jejuni enteritis
- Source :
- Journal of Neuroimmunology. 71:155-161
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- N-Acetylgalactosaminyl GD1a (GalNAc-GD1a) is a proposed target molecule for serum antibody in some patients with Guillain-Barre syndrome (GBS) (Kusunoki et al., 1994). We examined autoantibody to GalNAc-GD1a in sera from 58 GBS patients. Eight GBS patients had high IgG anti-GalNAc-GD1a antibody titers, 3 of whom also had high IgM anti-GalNAc-GD1a antibody titers. These 8 patients had experienced gastrointestinal infection before the onset of their neurological symptoms. Campylobacter jejuni was isolated from 4 of them. An absorption test indicated the presence of the GalNAc-GD1a epitope in lipopolysaccharides of C. jejuni. Sera that had anti-GalNAc-GD1a antibody reacted with several acidic glycolipids in bovine peripheral nerve, one of which was identified as N-acetylgalactosaminyl GM1b (GalNAc-GM1b). Serum binding to GalNAc-GM1b was decreased by absorption with GalNAc-GD1a. The presence of GalNAc-GM1b as well as GalNAc-GD1a has been reported in human peripheral nerves. We assume that C. jejuni, which bears the [GalNAc beta 1-4 (NeuAc alpha 2-3) Gal beta 1-3 GalNAc beta 1-] epitope, is the immunogen and that the glycoconjugates with the epitope are target molecules for the autoantibody in peripheral nerves of some GBS patients.
- Subjects :
- endocrine system
Immunogen
biology
Guillain-Barre syndrome
business.industry
Immunology
Autoantibody
Antibody titer
medicine.disease
biology.organism_classification
Campylobacter jejuni
Epitope
Enteritis
carbohydrates (lipids)
Neurology
parasitic diseases
biology.protein
medicine
Immunology and Allergy
lipids (amino acids, peptides, and proteins)
Neurology (clinical)
Antibody
business
Subjects
Details
- ISSN :
- 01655728
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmunology
- Accession number :
- edsair.doi...........c5ff9e8e5570052a6e82cea58529ca01