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Immunoadsorption therapy reduces oxidative stress in patients with dilated cardiomyopathy
- Source :
- World Journal of Cardiovascular Diseases. :305-312
- Publication Year :
- 2012
- Publisher :
- Scientific Research Publishing, Inc., 2012.
-
Abstract
- Several literatures have reported that the elimination of autoantibodies by immunoadsorption (IA) therapy induced short- and long-term improvements in cardiac function of patients with dilated cardiomyopathy (DCM). We assessed whether reduction in oxidative stress was related to the mechanism underlying left ventricular functional benefit from IA. We studied 7 patients with DCM (New York Heart Association (NYHA) functional class III/IV). Autoantibodies were removed with IA by passing patients’ plasma over tryptophan columns. The level of anti-β1-adrenoreceptor (AR) autoantibodies was measured by enzyme- linked immunosorbent assay. The level of diacron- reactive oxygen metabolite (d-ROM) was determined as a marker of oxidative stress. During IA, the anti- β1-AR autoantibodies titers of all the patients decreased significantly from 27.8 ± 5.0 to 18.7 ± 5.5 U/ml (p < 0.01). IA induced the following hemodynamic improvements: cardiac index increased from 1.71 ± 0.40 to 1.97 ± 0.41 l/min/m2 and left ventricular ejection fraction (LVEF) increased from 22.8 ± 6.1 to 29.1±9.1% (p < 0.05). d-ROM level decreased significantly from 392.7 ±17.0 to 314.1 ± 22.0 Carratelli units (p < 0.05), and was negatively correlated with LVEF before and after IA therapy (r = -0.601, p < 0.05). The anti-β1-AR autoantibodies, LVEF and d- ROM returned to the baseline levels at 12 months after IA. In conclusion, oxidative stress reduction may be responsible for the beneficial effect of IA therapy in patients with DCM.
- Subjects :
- Cardiac function curve
medicine.medical_specialty
Ejection fraction
business.industry
medicine.medical_treatment
Cardiac index
Hemodynamics
Dilated cardiomyopathy
medicine.disease
medicine.disease_cause
Endocrinology
Internal medicine
Cardiology
Medicine
Plasmapheresis
business
Immunoadsorption
Oxidative stress
Subjects
Details
- ISSN :
- 21645337 and 21645329
- Database :
- OpenAIRE
- Journal :
- World Journal of Cardiovascular Diseases
- Accession number :
- edsair.doi...........c5af6df6b71c9da1d931563ba3720661