Assessment of the genomic stability and molecular landscape of patient-derived xenograft (PDX) models from NCI’s Patient-Derived Models Repository (PDMR)

Authors :: John Mark Carter
Margaret R. DeFreytas
Li Chen
Michelle M. Gottholm-Ahalt
Melinda G. Hollingshead
Erin Cantu
Paul Williams
Corinne Camalier
Suzanne Borgel
Rajesh Patidar
Chris Karlovich
Vivekananda Datta
Palmer Fliss
Yvonne A. Evrard
Malorie Morris
Bishwajit Das
James H. Doroshow
Marianne Radzyminski
Gloryvee Rivera
Dianne L. Newton
Source :: Journal of Clinical Oncology. 36:12023-12023
Publication Year :: 2018
Publisher :: American Society of Clinical Oncology (ASCO), 2018.
Abstract: 12023Background: Patient-derived xenografts (PDXs) are a powerful tool for cancer translational research. However, it is unclear if early passage PDXs faithfully recapitulate the molecular profiles...

Subjects :: Cancer Research
Oncology
business.industry
Cancer research
medicine
Cancer
Translational research
Early passage
medicine.disease
business
humanities
Tumor xenograft
Genomic Stability

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