GW27-e1145 Chronic intracerebroventricular infusion of metformin inhibits salt-sensitive hypertension in rats via attenuation of oxidative stress in the hypothalamic paraventricular nucleus

Authors :: Yanan Zhao
Bin Liang
Zhi-Ming Yang
Jingjing Xue
Huiyu Yang
Source :: Journal of the American College of Cardiology. 68:C41
Publication Year :: 2016
Publisher :: Elsevier BV, 2016.
Abstract: This study was designed to determine whether metformin, an antidiabetic agent, exerts antihypertensive effects in rats with salt-sensitive hypertension through attenuation of oxidative stress in the hypothalamic paraventricular nucleus (PVN). Dahl salt-sensitive rats received a high-salt (HS, 8%

Subjects :: medicine.medical_specialty
business.industry
digestive, oral, and skin physiology
medicine.disease_cause
Metformin
Endocrinology
medicine.anatomical_structure
nervous system
Internal medicine
Salt sensitivity
Medicine
Cardiology and Cardiovascular Medicine
business
Nucleus
hormones, hormone substitutes, and hormone antagonists
Oxidative stress
medicine.drug

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