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Comparison of Post-mortem 7.0-Tesla Magnetic Resonance Imaging of the Brains of Alzheimer Patients with and without Cerebral Amyloid Angiopathy
- Source :
- OBM Geriatrics. 4
- Publication Year :
- 2020
- Publisher :
- LIDSEN Publishing Inc, 2020.
-
Abstract
- Purpose: The influence of cerebral amyloid angiopathy (CAA) in Alzheimer’s disease (AD) remains unexplored. The present post-mortem study investigated possible differences in the degree of hippocampal atrophy (HA) between AD patients with and without CAA using 7.0-tesla magnetic resonance imaging (MRI). Also, the incidence of the hippocampal cortical micro-infarcts (HCoMIs) and hippocampal cortical micro-bleeds (HCoMBs) is compared to those in the neocortex. Methods: The examined post-mortem brains included 30 AD-CAA cases and 20 AD without CAA cases. The samples of the hippocampus were evaluated on the most representative coronal section with T2 and T2* MRI sequences. The average degree of HA was determined in both groups. The incidences of HCoMIs and HCoMBs, along with the frequency of CoMIs and CoMBs in the neocortex were compared in both groups: AD-with CAA and AD without CAA cases. Results: No significant differences were observed in the degree of HA and the incidence of hippocampal micro-infarcts (HMIs) and hippocampal micro-bleeds (HMBs) between the AD-CAA and the AD brains in contrast to the higher incidence of these cerebrovascular lesions in the neocortex of AD-CAA brains. The incidence of CoMIs and CoMBs in the neocortex showed similarity to that in the hippocampus of AD patients without CAA. Conclusions: CAA does not influence the degree of HA and the incidence of micro-infarcts (MIs) and micro-bleeds (MBs) in the hippocampus, in contrast to the high contribution of the latter with CAA in the neocortex. The hippocampus seems to be more spared from cerebrovascular involvement than the other parts of the brain.
- Subjects :
- Pathology
medicine.medical_specialty
Neocortex
medicine.diagnostic_test
business.industry
nutritional and metabolic diseases
Hippocampus
Magnetic resonance imaging
Hippocampal formation
medicine.disease
Hippocampal atrophy
medicine.anatomical_structure
mental disorders
medicine
cardiovascular diseases
Cerebral amyloid angiopathy
business
Subjects
Details
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- OBM Geriatrics
- Accession number :
- edsair.doi...........c5526d81318d03b315662fc1355be17f