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Mild COVID-19 in an APECED Patient with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and High Titer of Type 1 IFN-Abs: A Case Report
- Source :
- Pathogens. 12:403
- Publication Year :
- 2023
- Publisher :
- MDPI AG, 2023.
-
Abstract
- Autoimmune-Poly-Endocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED), caused by mutations in the Autoimmune Regulator (AIRE) gene, is an autosomal recessive multi-organ autoimmunity syndrome usually defined by high serum titers of type I Interferon Autoantibodies (Type 1 IFN-Abs). These antibodies have recently been found in individuals in the general population who develop life-threatening Coronavirus Disease 2019 (COVID-19), but the significance of pre-existing Type 1 IFN-Abs in APECED patients with COVID-19 remains unclear. Previous reports of COVID-19 outcomes in APECED patients have been divergent, and protective roles have been proposed for female sex, age
Details
- ISSN :
- 20760817
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Pathogens
- Accession number :
- edsair.doi...........c4420768513cf23972107181443bbc8c