NUCLEAR ACTIVITY OF BLOOD CELLS

This paper presents the continuation of studies on blood cell behaviors published earlier by Engelbert.It was then shown that "nuclear bodies" named "basic nuclear units" passed through several stages of a nuclear life history which was believed to hold the key to blood cell cytogenesis. Blood cell polymorphism or pleomorphism is believed to be products of the many staged nuclear life history. The nuclear life history can be experimentally altered, for example by foreign proteins. The basic nuclear units are believed to be reproductive organelles.Additional evidence of nuclear behaviors fitting into the nuclear life history is presented. Formation and release of vesicles by myeloblast nuclei was demonstrated earlier. Evidence is presented here to show that the production and release of these intranuclear vesicles is not a sign of degeneration, but a process by which new cells can be produced through reassociation of released nuclear materials. Some released vesicles become red blood cells. Extreme variations in shape of myeloblast nuclei are not signs of degeneration, but are characteristic nuclear behaviors associated with nuclear activity.The release of new small nuclei, intranuclear vesicles, and various granules are nuclear activities leading to formation of new cells.