Psychosis High-Risk States

Psychosis High-Risk states are today a major field of research in psychiatry allowing early intervention (including primary prevention) of severe psychotic disorders. Psychosis High-Risk criteria select different clinical features and appear to be different center-wise and country-wise. As several of the phenomena accounting for symptoms are subjective in nature, both original and recent inputs from research in phenomenological psychopathology are great candidates for adding to the conceptual validity of High-Risk states. These subjects show a disturbed grip on reality–perplexity, derealization, and depersonalization—as well as a diminished presence in the world and involuntarily ruminating on things they previously ignored. Special sets of phenomena are presented including Truman symptoms, anomalous subjective self and world experiences, and abnormal bodily phenomena. Contemporary predictive and translational research will ultimately integrate phenomenological data with the neurocognitive and neurobiological models of mental disorders.