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Motivated by analogous applications to sonoluminescence, neutron stars mergers are examined in the context of Schwinger's dynamical Casimir effect. When the dielectric properties of the QED vacuum are altered through the introduction of dense matter, energy shifts in the zero-point fluctuations can appear as photon bursts at gamma-ray frequencies. The amount of radiation depends upon the properties and amount of matter in motion and the suddenness of the transition. It is shown that the dynamical Casimir effect can convert sufficient energy of neutron star mergers into gamma rays. Using information extracted from simulations of matter flow in neutron star mergers by Ruffert and Janka, we estimate that the total Casimir energy released can exceed 10 53 ergs in gamma-ray frequencies. The Casimir energy approach is capable of explaining the most energetic gamma-ray bursts.