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Controlled Drug Release from Gelatin-Sodium Carboxymethylcellulose Interpenetrating Polymer Networks
- Source :
- Journal of Macromolecular Science, Part A. 40:629-639
- Publication Year :
- 2003
- Publisher :
- Informa UK Limited, 2003.
-
Abstract
- Hydrogels of uncrosslinked gelatin, crosslinked gelatin (Gelx), and various compositions of semi-interpenetrating polymer network of cross-linked gelatin with uncross-linked sodium carboxymethylcellulose [Gelx-NaCMC] were investigated as potential matrices for substrate delivery. Simultaneous swelling behavior and controlled drug release under enzymatic conditions (erodible) were monitored for hydrogels of [Gelx-NaCMC] and Gelx. Results indicated a first order release indicating that the processes (rate of drug diffusion and degradation) do not follow the same kinetics.
- Subjects :
- chemistry.chemical_classification
food.ingredient
Materials science
Polymers and Plastics
Kinetics
General Chemistry
Polymer
Gelatin
Polyelectrolyte
food
chemistry
Chemical engineering
Polymer chemistry
Self-healing hydrogels
Materials Chemistry
Ceramics and Composites
medicine
Interpenetrating polymer network
Swelling
medicine.symptom
Drug carrier
Subjects
Details
- ISSN :
- 15205738 and 10601325
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Journal of Macromolecular Science, Part A
- Accession number :
- edsair.doi...........c311a56b466aa6d08bdc4d83a67ff791