Transition of cytomegalovirus seropositivity in Japanese puerperal women

Aim: To investigate the latest serological tendency of cytomegalovirus (CMV) in Japanese puerperal women and to estimate the sequential influence on child-bearing women in Japan. Methods: We studied 3966 puerperal women registered at a cord blood bank. Serum samples were obtained from umbilical cords at delivery and on the third day after delivery. CMV immunoglobulin G (IgG) and CMV immunoglobulin M (IgM) antibodies were determined using enzyme immunoassay kits. Scatter diagrams between seroprevalences and perinatal details were generated, and Pearson product-moment correlation coefficients (r) and coefficients of determination (R2) were calculated. Results: The overall CMV seroprevalence was 68.4% for the IgG antibody and 3.9% for the IgM antibody. IgM seroconversion had occurred separately in 0.28% of the cases without IgG seroconversion. Including outliers on scatter plots, linear decreasing trends were observed for IgG seropositivity with measurement year (r = −0.72, P