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Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis
- Publisher :
- Apollo - University of Cambridge Repository
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Abstract
- Objective: To establish a rigorous, expert-led, evidence-based approach to the evaluation of licensed drugs for repurposing and testing in clinical trials of people with progressive multiple sclerosis (MS). Methods: We long-listed licensed drugs with evidence of human safety, blood–brain barrier penetrance and demonstrable efficacy in at least one animal model, or mechanistic target, agreed by a panel of experts and people with MS to be relevant to the pathogenesis of progression. We systematically reviewed the preclinical and clinical literature for each compound, condensed this into a database of summary documents and short-listed drugs by scoring each one of them. Drugs were evaluated for immediate use in a clinical trial, and our selection was scrutinised by a final independent expert review. Results: From a short list of 55 treatments, we recommended four treatments for immediate testing in progressive MS: R-α-lipoic acid, metformin, the combination treatment of R-α-lipoic acid and metformin, and niacin. We also prioritised clemastine, lamotrigine, oxcarbazepine, nimodipine and flunarizine. Conclusions: We report a standardised approach for the identification of candidate drugs for repurposing in the treatment of progressive MS.
- Subjects :
- Multiple sclerosis
3. Good health
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........c2ca5e7962cb249632e0d2684f7c5611