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Guided bone regeneration with a gelatin layer and adenoviral delivery of c-myb enhances bone healing in rat tibia
- Source :
- Regenerative Medicine. 15:1877-1890
- Publication Year :
- 2020
- Publisher :
- Future Medicine Ltd, 2020.
-
Abstract
- Aim: Bone healing becomes problematic during certain states, such as trauma. This study verifies whether the application of c-myb with gelatin promotes bone healing during bone injuries. Materials & methods: A biodegradable membrane was modified with adenoviral vector c-myb ( Ad/c-myb) and gelatin and applied in the bone injury site of rat tibia. Results: c-myb enhanced osteogenic differentiation and mineralization in bone marrow stromal cells after induction with osteogenic media. In vivo examination of rat tibia after application of the biodegradable membrane with Ad/c-myb and a gelatin layer demonstrated increased bone volume, bone mineral density, new bone formation and osteogenic molecules, compared with Ad/LacZ. Conclusion: c-myb has the potential to assist bone healing and may be applicable to the treatment of bone during injury.
- Subjects :
- Bone mineral
0303 health sciences
Embryology
Pathology
medicine.medical_specialty
food.ingredient
Stromal cell
Chemistry
Bone Injury
medicine.medical_treatment
Biomedical Engineering
030206 dentistry
Bone healing
Bone grafting
Gelatin
03 medical and health sciences
0302 clinical medicine
food
medicine.anatomical_structure
medicine
Bone marrow
Bone regeneration
030304 developmental biology
Subjects
Details
- ISSN :
- 1746076X and 17460751
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Regenerative Medicine
- Accession number :
- edsair.doi...........c28bf052690530efb27d9adef1e5d873