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Association of obesity with tumor differential gene expression and gene set enrichment pathways in advanced prostate adenocarcinoma (PCa)
- Source :
- Journal of Clinical Oncology. 41:231-231
- Publication Year :
- 2023
- Publisher :
- American Society of Clinical Oncology (ASCO), 2023.
-
Abstract
- 231 Background: Increased Body Mass Index (BMI) has been linked to increased prostate cancer incidence, recurrence, and mortality (PMID: 35538398). Herein, we sought to investigate the underlying differences in gene expression profiles based on BMI in patients (pts) with PCa. Methods: In this IRB-approved retrospective study, eligibility criteria included histologically confirmed PCa and available RNA sequencing results from treatment naïve primary prostate tissue by a CLIA-certified lab. Pts were categorized into two cohorts: obese (Ob, BMI≥30) and non-obese (non-Ob, BMI
- Subjects :
- Cancer Research
Oncology
Subjects
Details
- ISSN :
- 15277755 and 0732183X
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Oncology
- Accession number :
- edsair.doi...........c20b666992610a6b7409fb3e1d0a2075