INDICATORS OF MANGANESE IN SERUM OF WOMEN WITH POLYCYSTIC OVARY AND ANALYSIS OF POSSIBLE SOURCES OF EXPOSURE

The goal of the work. Determine the level of manganese exposure in women withpolycystic ovary (PCOS) and analyze possible sources of exposure.Material and methods. The research was conducted in Kyiv. The first group (control)consisted of 38 women of reproductive age. The second group consisted of 52 women inwhom PCOS had been diagnosed. Using ICP-MS, a study of serum manganese in bothgroups of women was conducted. The study of environmental pollution with manganesewas carried out by processing data published in the open sources of information.Results. In women with PCOS, manganese values (median - 0.0095 mg/l, 95 percentile -0.13 mg/l) in serum were elevated, which significantly exceeded values from the controlgroup (median - 0.0035 mg/l, 95 -procetylene - 0.014 mg/l, p = 0.0012). Investigation ofpossible sources of exposure showed that drinking water could not be the cause ofexposure to manganese. Indicators of manganese in surface waters exceed the maximumpermissible values from 3,2 to 28 times. The level of air pollution by manganese inhundreds of times exceeded the safe levels for humans. Current article reviews differentpathogenic mechanisms of high concentration influence of manganese on PCOSoccurrence based on the type of exposure.Conclusion. High manganese concentrations in serum were found in women with PCOS.Sources of women's exposure are connected, probably, with high level of manganese insurface waters and air pollution. Both inhalatory and nutrient manganese exposurecreate pathogenic basis for PCOS.