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Phaseolus vulgaris leaves increase short chain fatty acids (SCFA) production ameliorating early metabolic alterations

Authors :
Adriana Araceli Becerril-Campos
Perla Viridiana Ocampo-Anguiano
Candelario Mondragón-Jacobo
Konisgmar Escobar-García
Mariela Camacho Barrón
Miriam Aracely Anaya-Loyola
Ana Angélica Feregrino-Perez
Teresa García-Gasca
Santiaga Marisela Ahumada-Solórzano
Publication Year :
2022
Publisher :
Research Square Platform LLC, 2022.

Abstract

High-fat/high-fructose diets promote early metabolic disorders in weight, lipid and glucose metabolism. Bioactive compounds such as polyphenols and fiber present in plant-based food prevent metabolic disorders development. The objective of the present study was to evaluate the effect of bean leaves on early metabolic alterations in Wistar male rats fed with high-fat/high-fructose diet. After proximate and chemical analysis of bean leaves, thirty-six Wistar male rats (ethical approval 06FCN2019 and 77FCN2019) were randomly assigned into one of four groups: 1) Standard diet (S) fed with Rodent Laboratory Chow 5001®, 2) Standard diet + 10% of dry bean leaves (SBL), 3) high fat (lard) and fructose diet (H) and 4) high-fat/high-fructose diet + 10% of dry bean leaves (HBL). The study was carried out for 6 weeks. Group H exhibited early metabolic alterations compared to S, final weight gain (↑15%), abdominal fat accumulation (↑11% waist circumference), triglycerides (↑30%), glucose (↑16%), insulin resistance (↑HOMA-IR 32%), fecal triglycerides (↑284%) and decreased total short chain fatty acid (↓SFCA, 17%). Bean leaves supplementation (HBL) compared to group H prevented body weight gain (↓12%), abdominal fat accumulation (waist circumference, ↓10%), early insulin resistance (glucose area under the curve, ↓6%). Probably mediated by the fiber and polyphenols present in the leaves, supplementary bean leaves-diet increased SFCA production (↑54%). Therefore, bean leaves are a low-cost alternative for human nutritional care and prevention of early metabolic alterations.

Subjects

Subjects :
food and beverages

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........c1b444753021c2e38c4366d4f5c55270
Full Text :
https://doi.org/10.21203/rs.3.rs-1551830/v1