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ChemInform Abstract: Syntheses of LewisXand Dimeric LewisX: Construction of Branched Oligosaccharides by a Combination of Preactivation and Reactivity Based Chemoselective One-Pot Glycosylations

Authors :
Xin-Shan Ye
Xuefei Huang
Youlin Zeng
Adeline Miermont
Yuqing Jing
Source :
ChemInform. 39
Publication Year :
2008
Publisher :
Wiley, 2008.

Abstract

Two asymmetrically branched oligosaccharides, LewisX and dimeric LewisX, were assembled in one pot with high yields and exclusive regio- and stereoselectivities. p-Tolyl thioglycosides were utilized as the sole type of building blocks, thus simplifying the overall synthetic design. The reactivity-independent nature of the preactivation based method allows modular assembly of the dimeric LewisX octasaccharide without the need for tedious protective group manipulation to achieve exact anomeric reactivities.

Details

ISSN :
15222667 and 09317597
Volume :
39
Database :
OpenAIRE
Journal :
ChemInform
Accession number :
edsair.doi...........c1ab934bc79708a372b8fd27af72c1ed