Induction and molecular regulation of host cell apoptosis by infectious pancreatic necrosis virus infection

Apoptosis is an active process of cell death that serves diverse functions in multicellular organisms, and under physiological conditions it is tightly controlled. Apoptosis is often implicated in the elimination of cells whose survival might be harmful to the organism as a whole; for example, mechanisms have evolved to target virus-infected cells for apoptotic cell death. Infectious pancreatic necrosis virus (IPNV) is an economically important fish pathogen belonging the to Birnaviridae virus family. E1-S of IPNV Ab strain was isolated from the Japanese eel in Taiwan. In this review, we disucss how IPNV-El-S iduces the CHSE-214 cells from the apoptotic features at the onset of pathology to postapoptotic necrosis. The virus gene expression also has a possible involvement with Mcl-1 for the regulation of apoptosis in these cells. This ewview may provide some insight into the control of IPNV replication.