A Phase 3 Trial of<scp>l</scp>-Glutamine in Sickle Cell Disease

Authors :: Edouard Guillaume
Lance Sieger
Kusum Viswanathan
Lewis L. Hsu
Elliott Vichinsky
Sophie Lanzkron
Osbourne A. Blake
Ifeyinwa Osunkwo
Rita Bellevue
Wally R. Smith
Eduard H. Panosyan
Tamara New
Swayam Sadanandan
Lan T. Tran
Rafael Razon
Sharada A. Sarnaik
Julie Kanter
Charles W Stark
Lynne Neumayr
Joseph L. Lasky
Victor R. Gordeuk
Scott T. Miller
Yutaka Niihara
Source :: New England Journal of Medicine. 379:226-235
Publication Year :: 2018
Publisher :: Massachusetts Medical Society, 2018.
Abstract: Background Oxidative stress contributes to the complex pathophysiology of sickle cell disease. Oral therapy with pharmaceutical-grade l-glutamine (USAN, glutamine) has been shown to increa...

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