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93. Phosphorylated α-synuclein biomarker in skin nerves is differently expressed in pure autonomic failure and idiopathic Parkinson disease
- Source :
- Clinical Neurophysiology. 127:e153-e154
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- The aim of this study was to characterize the expression in skin nerves of native (n-syn) and misfolded or phosphorylated (p-syn) α-synucleins in pure autonomic failure (PAF) and idiopathic Parkinson disease (IPD). We studied 30 patients, including 16 well-characterized IPD, 14 patients fulfilling PAF diagnostic criteria, and 15 age-matched controls. Subjects underwent skin biopsy from cervical, thigh and leg sites to study small nerve fibers and intraneural n-syn and p-syn. PAF and IPD both showed a skin denervation, more severely expressed in patients with higher p-syn load. N-syn was similarly expressed in both groups of patients and controls. By contrast, p-syn was not found in controls, but it was disclosed in all PAF and IPD patients with different skin innervation. In addition, abnormal α-syn deposits were found in all analysed skin samples in PAF, but in 49% of samples only with higher positivity rate in the cervical site in IPD. In conclusion: (1) intraneural p-syn was a reliable in vivo marker of PAF and IPD; (2) neuritic p-syn inclusions differed in PAF and IPD, suggesting a different underlying pathogenesis; (3) searching for abnormal p-syn deposits in skin nerves, the site of analysis is irrelevant in PAF, but it is critical in IPD.
- Subjects :
- Denervation
Pathology
medicine.medical_specialty
medicine.diagnostic_test
business.industry
animal diseases
Disease
bacterial infections and mycoses
medicine.disease
Sensory Systems
nervous system diseases
Pathogenesis
nervous system
Neurology
In vivo
Physiology (medical)
Skin biopsy
Phosphorylated α synuclein
medicine
Biomarker (medicine)
heterocyclic compounds
Neurology (clinical)
business
Pure autonomic failure
Subjects
Details
- ISSN :
- 13882457
- Volume :
- 127
- Database :
- OpenAIRE
- Journal :
- Clinical Neurophysiology
- Accession number :
- edsair.doi...........c0bd42df64f8277c1ec76d8fb32c0cbf