TiO2 nano crystallites catalyzed water mediated microwave assisted regioselective three component domino hydrolysis/aldol condensation/Michael addition reaction of 3-(1,5-dioxo-1,5-diphenylpentan-3-yl)quinolin-2(1H)-one

A facile microwave supported, water intervened and nano crystalline TiO2 catalyzed synthesis of 1,5-dicarbonyl derivatives, 3-(1,5-dioxo-1,5-diphenylpentan-3-yl)quinolin-2(1H)-ones, is described. This strategy utilizes the reversible water adsorption/de-sorption property of TiO2 nano crystallites for the domino hydrolysis/aldol condensation/Michael addition. The current methodology provides the coveted synthetic building blocks in an ecologically benevolent procedure, including a reusable catalyst, safe, universal water medium, microwave support, a multistep reaction in one pot and a selective process.