Formulation and In Vitro evaluation of Gastroretentive Ofloxacin floating tablets using natural polymers

The objective of the present study was to formulate and evaluate the gastro retentive floating tablets of ofloxacin and to improve its bioavailability. Ofloxacin gastroretentive floating tablets were prepared employing natural polymers using wet granulation method. Six formulations were prepared in different concentrations by using Tamarind seed polysaccharide (TSP) and pectin and evaluated for pharmaco technical parameters. FT-IR studies demonstrated that there is no evidence of interaction with drug, polymers and excipients. The prepared formulations were evaluated for the precompression parameters and were in the acceptable limits. Physical characteristics, in vitro drug release, buoyancy lag time and swelling index were performed. The in vitro drug release profile showed that formulation (F2) containing tamarind seed polysaccharide exhibited 95.4% of drug release at the end of 12 h. The in vitro drug release kinetics reveals that the formulation F2 followed zero order kinetics and the mechanism of drug release was found to be non fickian. Among all the formulations, F2 can be considered as the promising formulation in releasing the drug up to 12 h.