ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF AN ETHANOL EXTRACT OF DUNALIELLA SALINA TEOD. (CHLOROPHYCEAE)

This study investigated the analgesic and anti-inflammatory effects of an ethanol extract of Dunaliella salina Teod. (Chlorophyceae) (EDS) in Imprint- ing Control Region mice. Standard all-trans-b-carotene and the amount of all-trans-b-carotene in an EDS were analyzed by high-performance liquid chromatography (HPLC). In HPLC analysis, the fingerprint chromatogram of EDS was established. Both all-trans-b-carotene and EDS showed similar peaks at the retention time of 24 min. This implied that EDS contained the active ingredient all-trans-b-carotene. Treatment of animals with EDS significantly inhibited the numbers of acetic acid-induced writhing responses at doses of 0.5 g/kg (P < 0.01)