Material Chemistry of Two-Dimensional Inorganic Nanosheets in Cancer Theranostics

Summary Recent advances in two-dimensional (2D) chemistry have led to the rapid development of research on the emerging 2D inorganic nanomaterials in various fields, such as condensed matter physics, material science, chemistry, biology, and nanotechnology. As a special cross-disciplinary research frontier, 2D inorganic nanosheets for oncological applications, which are capable of accomplishing desirable theranostic performance, have attracted great attention from the scientific community in recent years. In this review, we summarize the underlying fundamental principles for the material chemistry of the 2D inorganic family in cancer theranostics and nano-enabled amalgamation of material chemistry and oncology on the basis of the recent progress in theranostic platforms based on 2D inorganic nanosheets. Moreover, current challenges and perspectives on the development of 2D inorganic nanosheets for further clinical translations are also discussed. It is expected that this emerging 2D inorganic family will play a vital role in next-generation cancer theranostics.