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Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra

Authors :
Juan Segura-Aguilar
Pablo Caviedes
Pedro Martinez-Alvarado
Marcelo N. N. Vieira
Rita Raisman-Vozari
Sergio Cardenas
Claudio Olea-Azar
Carolina Perez-Pastene
Irmgard Paris
Rebeca Graumann
Source :
Journal of Neurochemistry. 92:1021-1032
Publication Year :
2005
Publisher :
Wiley, 2005.

Abstract

The role of dopamine in iron uptake into catecholaminergic neurons, and dopamine oxidation to aminochrome and its one-electron reduction in iron-mediated neurotoxicity, was studied in RCSN-3 cells, which express both tyrosine hydroxylase and monoamine transporters. The mean ± SD uptake of 100 µm59FeCl3 in RCSN-3 cells was 25 ± 4 pmol per min per mg, which increased to 28 ± 8 pmol per min per mg when complexed with dopamine (Fe(III)–dopamine). This uptake was inhibited by 2 µm nomifensine (43%p

Details

ISSN :
14714159 and 00223042
Volume :
92
Database :
OpenAIRE
Journal :
Journal of Neurochemistry
Accession number :
edsair.doi...........bfb35da0300ac07eeecf1b30c56b8bd3
Full Text :
https://doi.org/10.1111/j.1471-4159.2004.02931.x