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Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra
- Source :
- Journal of Neurochemistry. 92:1021-1032
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- The role of dopamine in iron uptake into catecholaminergic neurons, and dopamine oxidation to aminochrome and its one-electron reduction in iron-mediated neurotoxicity, was studied in RCSN-3 cells, which express both tyrosine hydroxylase and monoamine transporters. The mean ± SD uptake of 100 µm59FeCl3 in RCSN-3 cells was 25 ± 4 pmol per min per mg, which increased to 28 ± 8 pmol per min per mg when complexed with dopamine (Fe(III)–dopamine). This uptake was inhibited by 2 µm nomifensine (43%p
- Subjects :
- medicine.medical_specialty
biology
Tyrosine hydroxylase
Chemistry
Biochemistry
Cellular and Molecular Neuroscience
Nomifensine
Norepinephrine
Monoamine neurotransmitter
Endocrinology
Norepinephrine transporter
Dopamine
Internal medicine
Catecholamine
medicine
biology.protein
Catecholaminergic cell groups
medicine.drug
Subjects
Details
- ISSN :
- 14714159 and 00223042
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Journal of Neurochemistry
- Accession number :
- edsair.doi...........bfb35da0300ac07eeecf1b30c56b8bd3
- Full Text :
- https://doi.org/10.1111/j.1471-4159.2004.02931.x