2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis

As part of an effort to define the pharmacophore and discover the mechanism by which the antiinflammatory dual cyclooxygenase / 5-lipoxygenase inhibitors SK&F 86002 and SK&F 105809 inhibit IL-1 biosynthesis, a series of substituted 2,4,5-triarylimidazole derivatives were prepared and evaluated as inhibitors of IL-1 and 5-lipoxygenase biosynthesis.