Elimination and reduction of chlorinated solvents in preparative liquid chromatography

Increasing safety concerns and environmental legislation have mandated the reduction and eventual elimination of chlorinated solvents. Therefore, the Preparative Chromatography Group at Searle is working to eliminate the use of chlorinated solvents. Three areas of investigation to meet this goal are under way: (1) develop replacement solvents, (2) reduce the percentage of chlorinated solvents and (3) develop alternative sample application techniques. This paper demonstrates the progress that has been made in all three areas.