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Unnatural tetradeoxy echinocandins produced by gene cluster design and heterologous expression

Authors :
Xionghui Yu
Qian Jiang
Xiaona Chen
Hongjun Shu
Yushan Xu
Huan Sheng
Yuchao Yu
Wenjie Wang
Nancy P. Keller
Jinzhong Xu
Pinmei Wang
Source :
Organic & Biomolecular Chemistry. 21:3552-3556
Publication Year :
2023
Publisher :
Royal Society of Chemistry (RSC), 2023.

Abstract

Heterologous expression of the designed echinocandin biosynthetic gene cluster in the chassis strain results in the production of two novel tetradeoxy echinocandins, one of which has superior stability and antifungal activity to echinocandin B.

Details

ISSN :
14770539 and 14770520
Volume :
21
Database :
OpenAIRE
Journal :
Organic & Biomolecular Chemistry
Accession number :
edsair.doi...........bf2ee5a895932826e7473b94d789555f