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Developmental validation of 15 X chromosomal short tandem repeat markers

Authors :
Adrian Linacre
Michael D. Coble
Toni M. Diegoli
Source :
Forensic Science International: Genetics Supplement Series. 4:e142-e143
Publication Year :
2013
Publisher :
Elsevier BV, 2013.

Abstract

The use of X chromosomal short tandem repeat (STR) markers has been greatly increasing in the forensic setting. Using guidelines set forth previously for the validation of autosomal and Y STRs, aspects of the feasibility of routine X chromosomal STR use were evaluated. Two mini-X chromosomal STR multiplexes capable of amplifying 15 total markers were developed and utilized to determine allele nomenclature, allele/genotype frequencies, mutation rates, and linkage between markers. Additionally, a concordance study between these multiplexes and a commercially available kit was performed. Here, the authors present an overview of this extensive developmental validation study.

Details

ISSN :
18751768
Volume :
4
Database :
OpenAIRE
Journal :
Forensic Science International: Genetics Supplement Series
Accession number :
edsair.doi...........bf135753966e3b229dc13bc694a6f19b
Full Text :
https://doi.org/10.1016/j.fsigss.2013.10.074