Synthesis of phenylalkyl-substituted polyhydroxypiperidines as potent inhibitors for α-l-fucosidase

Synthesis and inhibitory activities against α- l -fucosidase of phenylalkyl-substituted polyhydroxypiperidines have been described. Among the newly synthesized compounds, 2,4,6-trichloro derivative (16q) showed very high inhibitory activity against α- l -fucosidase with IC50 value of 0.005 μM, and Ki values of 0.0011 μM, respectively.